An "Omics" Based Survey of Human Colon Cancer (Proteomics)

Differential expression proteomics of human colon cancer.

The focus of this study was to use differential protein expression to investigate operative pathways in early stages of human colon cancer. Colorectal cancer represents an ideal model system to study the development and progression of human tumors, and the proteomic approach avoids overlooking posttranslational modifications not detected by microarray analyses and the limited correlation betwee...

Comparative Proteomics Analysis of Human Colon Cancer

Nutrition has evolved from providing nutrients to nourish populations to improving health of individuals through diet. Modern nutritional research focuses on health promotion and disease prevention, on protection against toxicity and stress, and on performance improvement. The concept of developing nutritionally enhanced or functional food requires (a) the understanding of the mechanisms of pre...

Application of laser capture microdissection and proteomics in colon cancer.

AIMS Laser capture microdissection is a recent development that enables the isolation of specific cell types for subsequent molecular analysis. This study describes a method for obtaining proteome information from laser capture microdissected tissue using colon cancer as a model. METHODS Laser capture microdissection was performed on toluidine blue stained frozen sections of colon cancer. Tum...

Screening for novel protein targets of indomethacin in HCT116 human colon cancer cells using proteomics

Non-steroidal anti-inflammatory drugs, such as indomethacin (IN), inhibit colorectal cancer (CRC) growth through cyclooxygenase (COX)-independent mechanisms, however, the precise biological mechanisms are not completely understood. The aim of the present study was to investigate new molecular factors potentially associated with IN in HCT116 human CRC cells, which do not express COX, using a pro...

proteomics study of polyethylenimine interaction with cell surface proteins in human colon adenocarcinoma cell line